Philippa Marrack, PhD, is a researcher at National Jewish Health. Dr. Marrack serves as Chair of the Department of Immunology and Genomic Medicine.
Special Interests
Research Interests
Most of our work over the years has focused on T cells. T cells are amongst the cells which recognize that an infection is occurring in the body. They accomplish this in an unexpected way, by reacting with fragments of the infection bound to special proteins of the body, the MHC proteins. We are trying to find out how T cells learn to react in this way. We are also interested in the ways in which T cells are prevented from attacking MHC proteins bound to fragments of their own host. In most people such attack is efficiently avoided. However, in some individuals T cells do react in this way, and this event causes autoimmune diseases such as rheumatoid arthritis and juvenile diabetes. However we do also study B cells, in particular a previously under investigated type of B cell (ABC) we first found in elderly female mice, but which has also been found by others and ourselves in women and mice with autoimmune diseases and in mice and humans with various infections including SARS-CoV In m
Marrack, Philippa (–)
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Philippa Marrack para niños
Philippa MarrackFRS (Ewell, Inglaterra, 28 de junio de ) es una bióloga, inmunóloga, bioquímica, investigadora y catedráticainglesa radicada en los Estados Unidos. Es conocida por sus investigaciones sobre el desarrollo, apoptosis y supervivencia de las células T; los adyuvantes inmunológicos; las enfermedades autoinmunes; y por identificar los superantígenos, el mecanismo detrás del síndrome del choque tóxico. Trabaja en colaboración con su marido, el académico e investigador estadounidense John W. Kappler.
Biografía
Philippa Marrack nació el 28 de junio de en Ewell, Inglaterra. Completó sus estudios de pregrado en y el doctorado en en el New Hall College de la Universidad de Cambridge. Durante su doctorado trabajó con Alan Munro en el Laboratorio de Biología Molecular del Consejo de Investigación Médica del Reino Unido, donde comenzó a estudiar las diferencias entre las células T y las células B. Realizó investigación postdoctoral con Richard Dutton en la Universidad de California en San Diego de a y ahí conoció a John W. Kappler.
Al terminar su trabajo en San Diego se casó con Kappler y ambos se trasladaron a Rochester, Nueva York, donde su m
To many undergraduates, intermediary metabolism means late nights in the library, eyes glazed while trying to memorize the intricacies before the next morning’s exam. To Philippa Marrack, these biochemical pathways meant a gratifying cerebral jolt. Suddenly she understood how the body extracts energy from the food we eat.
When these processes hooked her in the mid s, Marrack was studying science and mathematics at Cambridge University. She stayed there for her Ph.D. and joined a lab
that investigated what would be named T cells. The subject matter didn’t yet compel her: These immune cells had been discovered only a few years earlier, so no one knew whether they’d do anything interesting. Rather, she made the thesis choice because her advisor worked at an exciting place. The scintillating intellectual environment of the U.K.’s biochemical hub, the Medical Research Council’s Laboratory of Molecular Biology, seduced her.In the early s as a postdoc, Marrack met John Kappler, who would become her husband and scientific partner. By the decade’s end, immunologists had realized that T cells recognize chunks of foreign proteins—or antigens—only if they simultaneously detect particula
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